CURCUMIN ω

A promising but unavailable asset

Curcumin is often recommended for its virtues. It has been the subject of numerous scientific studies and continues to fuel the hopes of researchers with spectacular results in-vitro. The prospects of transposing the results to the body have been limited until now because of the very low bioavailability and the difficulty for manufacturers to extract it.

the limits of ordinary processes

Its low bioavailability is related to its liposolubility. Less than 1% of Curcuminoids are assimilated by the body in their standard form. To counter this low assimilation due to the liposolubility of curcumin, the association with piperine (black pepper extract) is currently used. This increases intestinal permeability by creating micro-lesions serving as a gateway to turmeric, with the disadvantage of increasing non-selective permeability and the passage of other substances and toxins. Some studies have shown the appearance of food intolerances and allergies among others. Nevertheless, these results must be weighted on a case-by-case basis given the considerable doses often involved in the studies cited (>40mg/d/kg in rodents). Beyond the reservations expressed and the hopes raised, piperine does not seem to us to increase bioavailability significantly enough compared to other strategies.

Encapsulation techniques are also used to increase bioavailability. These techniques include liposomes because of their ability to solubilize hydrophobic components, but the improvements observed are still not very conclusive.
the limits of ordinary processes.

the pitfall of liposolubility

To meet these challenges, we pursued two objectives: to increase the total bioavailability of curcuminoids and to refine the processes allowing higher concentrations in a liquid form. Based on the experiments we have conducted, the choice was made to use a dispersion of Curcuminoid nanoparticles supportedby hydrophilic agents that cause a partial solubilization.

Curcumin ω, Solubilization and Nanodispersion

In order to counteract this poor uptake, we have developed a form of curcumin that achieves a synthesis between nanodispersion and solubilization. This results in an easier transport at the intestinal level and not in an increase of the permeability with piperine. This passive transport is the pathway used in the case of encapsulated curcumin and which allows such an increase in bioavailability. However, unlike encapsulated forms, the water-soluble form of Curcumin ω avoids the use of surfactants, and any chemical additives. The new generation of Curcumin ω has also increased the concentration of curcumin of increased bioavailability from 50mg/100ml to 1200mg/100ml.

ⁱ Travaux de Recherche étudiant les effets favorables de la Curcumine sur l’Arthrose : un nouveau paradigme et une opportunité thérapeutique pour le traitement de l’arthrose
²Travaux de recherche visant à établir les effets de la curcumine sur le Stress oxydant : croissance tumorale et l’angiogenèse dans les cancers de l’ovaire en ciblant la voie du facteur nucléaire kappaB.
³ Travaux de Recherche étudiant les effets favorables de la Curcumine sur l’inflammation : Effets de la curcumine sur les concentrations sériques de cytokines chez les sujets atteints du syndrome métabolique:
⁴ Travaux de recherche démontrant les effets positifs de la Curcumine sur des utilisateurs en bonne santé
⁵ Travaux de recherche visant à mettre en évidence les effets de la Curcumine sur la dyslipidémie et de façon générale sur les facteurs de développement d’un  “syndrome métabolique”

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