Curcumin is the active ingredient of turmeric. It is the main curcuminoid of curcuma longa (about 80%). It is part of the curcuminoids (desmethoxycurcumin, bidesmethoxycurcumin, dihydrocurcumin). They give the yellow coloring to the rhizome of turmeric from which they are extracted.
A promising but unavailable asset
Curcumin is often recommended for its virtues. It has been the subject of numerous scientific studies and continues to fuel the hopes of researchers with spectacular results in-vitro. The prospects of transposing the results to the body have been limited until now because of its very low bioavailability and the difficulty for manufacturers to extract it.
Its low bioavailability is related to its liposolubility. Less than 1% of Curcuminoids are assimilated by the body in their standard form. To counter this low assimilation due to the liposolubility of curcumin, the association with piperine (black pepper extract) is currently used. This increases intestinal permeability by creating micro-lesions serving as a gateway to turmeric, with the disadvantage of increasing non-selective permeability and the passage of other substances and toxins. Some studies have shown the appearance of food intolerances and allergies among others. Nevertheless, these results must be weighted on a case-by-case basis given the considerable doses often involved in the studies cited (>40mg/d/kg in rodents). Beyond the reservations expressed and the hopes raised, piperine does not seem to us to increase bioavailability significantly enough compared to other strategies.
Encapsulation techniques are also used to increase bioavailability. These techniques include liposomes because of their ability to solubilize hydrophobic components, but the improvements observed are still not very conclusive.
the limits of ordinary processes
the pitfall of liposolubility
To address these issues, we pursued two objectives: to increase the total bioavailability of curcuminoids and to refine the processes allowing higher concentrations in a liquid form. Based on the experiments we conducted, the choice of a dispersion of Curcuminoid nanoparticles supported by hydrophilic agents at the origin of a partial solubilization was imposed.
The advanced research of the main ingredient company® has developed a liquid curcumin
- ensuring an increased natural assimilation, without chemical additives or surfactants.
- The liquid curcumin is a natural product, inducing a solubilization of a part of the curcuminoids fraction.
The research and development work of the main ingredient company® have resulted in a nanodispersed and solubilized curcumin with increased bioavailability, at significant concentrations (1200mg/100g, Curcumin ω)
"we are pursuing two goals: to offer a highly bioavailable form and to develop new processes allowing for higher concentrations on a liquid basis."
Solubilization and Nanodispersion
In order to counteract this poor uptake, we have developed a form of curcumin that achieves a synthesis between nanodispersion and solubilization. This results in an easier transport at the intestinal level and not in an increase of the permeability with piperine. This passive transport is the pathway used in the case of encapsulated curcumin and which allows such an increase in bioavailability. However, unlike encapsulated forms, the water-soluble form of Curcumin ω avoids the use of surfactants, and any chemical additives. The new generation of Curcumin ω has also increased the concentration of curcumin of increased bioavailability from 50mg/100ml to 1200mg/100ml.
Standardized curcuminoid bioavailability
Curcumin + Piperine
Bioavailability Curcumin ω 2.0
understand and objectify
Efficiency factor (F)
Titrated curcumin VS bioavailability VS real efficacy
The effectiveness of curcumin is supported by numerous studies linking its use to the improvement of the condition of users in various contexts. This effectiveness is based on two factors: the quantity of the product and the ratio between this quantity and the actual proportion of curcumin likely to reach the vascular system. The main ingredient company has succeeded in stabilizing curcumin in an effective form with the effect of significantly increasing its bioavailability. It is the combination of a titration of 1200mg/100g (3g/250ml) and its assimilability that conditions the objective performance of Curcumin ω measured by the efficacy factor (F).
the main ingredient company® innovates in the extraction, concentration and bioavailability of complex natural molecules.